DMSO IV Therapy

This page covers DMSO IV Therapy including its many benefits. IV League provides mobile DMSO IV Therapy.

Chemically, DMSO stands for dimethyl sulfoxide. It is offered both as a prescription drug and a food supplement.

It may be consumed orally, administered topically to the skin, or injected directly into the veins (used intravenously or by IV).

Organic liquid that is highly polar and is frequently employed as a chemical solvent. It serves as a delivery system for medications applied topically because of its capacity to penetrate biological membranes.

In cryopreservation, it is also employed to safeguard tissue. A variety of pharmacological activities, such as analgesia and anti-inflammation, are demonstrated by dimethyl sulfoxide.

Complex regional pain syndrome, bladder inflammation (interstitial cystitis), limb pain that typically develops after an accident, and intravenous (IV) medication leakage into nearby skin and tissue are all conditions that can be treated with DMSO (extravasation).

It is also used for other conditions; however, the majority of these uses are not well-supported by science.

DMSO is a prescription drug and dietary supplement. It can be ingested, administered topically to the skin, or injected into the veins (used intravenously or by IV).

DMSO is administered intravenously, topically, or orally to treat amyloidosis and its symptoms. A disorder known as amyloidosis causes aberrant protein deposition in organs and tissues.

DMSO is applied topically to wounds, burns, and muscular and skeletal injuries to lessen discomfort and hasten healing.

Additionally, DMSO is applied topically to treat excruciating illnesses like headache, inflammation, osteoarthritis, rheumatoid arthritis, and tic douloureux, a severe form of face agony.

It is applied topically for conditions affecting the eyes, such as cataracts, glaucoma, and issues with the retina, as well as for conditions affecting the feet, such as bunions, calluses, and toenail fungus.

When chemotherapy escapes from the IV used to give it, it is occasionally applied topically to repair skin and tissue damage. DMSO is used to relieve shingles pain either by itself or in conjunction with a medication called idoxuridine (herpes zoster infection).

DMSO is used intravenously to reduce the brain’s unusually high blood pressure. Additionally, it is used intravenously to treat interstitial cystitis, a bladder infection, and chronic inflammatory bladder disease.

Certain DMSO products have received FDA approval for use in the bladder to treat the signs and symptoms of chronic inflammatory bladder disease. To treat bile duct stones, DMSO is occasionally injected along with other drugs into the bile ducts.

DMSO is employed in production as an industrial solvent for antibiotics, plant hormones, fungicides, and herbicides.

DMSO has medically beneficial qualities such as causing anti-inflammation, nerve blocking (analgesia), diuretics, vasodilation, and muscle relaxation, even though it is often administered at relatively low concentrations.

Additionally, DMSO is employed in cell biology as a cryopreservative, a free radical scavenger, and an inducer of cell differentiation. Research cell cultures are frequently kept in liquid nitrogen using a gradual cooling technique. Cells are gradually cooled to 80 degrees in the presence of 10% DMSO before being stored in liquid nitrogen to prevent harm from intracellular ice crystals.

However, for biomedical applications, this method is insufficient. Human oocytes and embryos are cryopreserved for in vitro fertilization (IVF) by vitrification, which uses higher concentrations of cryoprotectants to stop ice formation not just in the cells but also in the entire solution.

This is done because slow cooling still causes damage from extracellular ice crystals. Combinations (for example, 15% DMSO and 15% ethylene glycol) can be used to produce higher concentrations while lowering the quantity and toxicity of the individual cryoprotectants.

Additionally, DMSO easily penetrates the majority of lower animal and human tissue membranes. For instance, DMSO had reached all of the examined hard and soft tissues in rats 2 hours after initial administration.

Additionally, DMSO has the ability to increase the permeability of other low molecular weight substances, enabling them to penetrate tissues more deeply or pass across membranes than they otherwise would. This ability is very helpful in topological therapies.

In 2009, PENNSAID®, which includes diclofenac in a carrier containing 45.5% DMSO, became the first product to receive FDA approval for topological DMSO administration.

Since skin is more difficult to penetrate than cell membranes, topological applications require a relatively large concentration of DMSO.

In the 20th century, high dosages of DMSO were frequently used to gain the majority of insights into its molecular actions. In the meanwhile, epigenome alterations and microRNA-mediated gene silencing have emerged as new research areas in biomedical science, as have more sensitive high-throughput approaches.

We examined a relatively low dose of DMSO (0.1%, which is frequently used in cell assays) to examine the effects on the proteome, transcriptome, and epigenome because of its widespread use in many biological domains.

For this, we exposed in vitro 3D microtissues (a developing heart model derived from iPSCs and a mature hepatic model) to 0.1% DMSO and collected samples in triplicate at seven distinct time intervals throughout the course of two weeks exposure (2 h, 8 h, 24 h, 72 h, 168 h, 240 h, and 336 h).

Then, using ribo-depleted total RNA sequencing and microRNA sequencing, whole-genome methylation profiling (using MeDIP-seq), and proteomics analysis, the effects of DMSO were evaluated (using mass spectrometry).

Our findings clearly showed that DMSO cannot be regarded as biologically inactive because it causes significant changes to the epigenetic and microRNA (miRNA) landscape, particularly in the developing cardiac model.

Benefits of DMSO IV Therapy

The FDA authorized DMSO to assist treat interstitial cystitis in the late 1970s. It is still the only bladder installation (or bladder wash) for this ailment that has received FDA approval.

DMSO has been demonstrated to improve interstitial cystitis symptoms in people:

• the condition helps to ease the pain
• the bladder is relaxed with its help
• capacity of bladder is increased

DMSO is frequently used as an alternative treatment to lessen inflammation and pain in off-label uses.

DMSO may be an advantageous substitute for conventional painkillers because it readily absorbed through the skin. Before any generalizations can be made, more research must be done in this area.

DMSO has also been praised for its capacity to lessen leakage when administering chemotherapy, although further research and practical use are required before it can be regarded as a reliable technique.

There has also been some investigation on the advantages of DMSO for the inhibition of cancer cells. There is evidence of benefit, according to a 2020 study published in the Journal of Medical Discovery. But as this field of study is just getting started, much more research must be done before any conclusions can be drawn.

There are several applications for the hygroscopic solvent and free radical scavenger known as dimethyl sulfoxide (DMSO) in both people and animals. It is given the ARCI’s Uniform code 4/C.

Defining the categories of foreign substances. There are over 30 pharmacological characteristics associated with DMSO. It can be given orally, intravenously, topically, and intra-articularly.

It is frequently used to reduce inflammation from the root cause and to carry other therapeutic chemicals into the body through the skin. The only FDA-approved use for DMSO in veterinary medicine is as a topical treatment to lessen acute edoema brought on by trauma.

The mucous membranes and skin can both be penetrated by DMSO without compromising their integrity. It passes the blood-brain barrier and pierces microorganisms and cell membranes. Because of its permeability, it can be utilized to boost the skin’s absorption of other medications (e.g., corticosteroids).

DMSO at least triples the rate of percutaneous absorption of corticosteroids. The anti-inflammatory, antibacterial, and antifungal properties of DMSO are also employed. Providing analgesia, reducing platelet application to lessen immediate swelling caused by trauma, aggregation, and a minor cholinesterase-inhibiting impact are some of the other benefits.

In addition to these illnesses, DMSO has also been used to treat colic, endotoxemia, reperfusion injury, some reproductive problems, and most frequently open wounds. However, there aren’t enough relevant, carefully-controlled trials to support many of the uses of DMSO.

Commercially, DMSO is offered in both liquid and gel form (DomosoTM and generics). Both are 90% by volume prepared and solely intended for external usage. According to the disease, the protocol for combining medications, and the preferences of the doctor, dosages vary greatly.

Following topical application, DMSO is quickly absorbed and widely dispersed throughout the body. A byproduct of the production of paper is DMSO. It may also be present in feedstuffs, such as lucerne (alfalfa) hay, and occurs naturally in trace amounts in fresh, oceanic, and rainfall.

Consequently, minor DMSO concentrations could detected in the plasma or urine of horses that did not receive therapeutic doses of DMSO.

The anti-inflammatory, analgesic, and enzyme activator/inhibitor properties of DMSO have been demonstrated. Due to its impact on the immune system and the prevention of tissue damage brought on by endotoxins, it may also have some bacteriostatic qualities.

In one investigation, joints with chemically induced synovitis that had been treated with DMSO had considerably lower white blood cell (WBC) counts in the synovial fluid.

DMSO still possesses medically beneficial effects, such as causing anti-inflammation, nerve blocking (analgesia), diuretics, vasodilation, and muscle relaxation, even though it is often administered at low concentrations9.

Additionally, DMSO is employed in cell biology as a cryopreservative, a free radical scavenger, and an inducer of cell differentiation. Research cell cultures are frequently kept in liquid nitrogen using a gradual cooling technique. Cells are gradually cooled to 80 degrees in the presence of 10% DMSO before being stored in liquid nitrogen to prevent harm from intracellular ice crystals.

DMSO is regarded by many as a universal solvent that can effectively dissolve both polar and nonpolar molecules in addition to its usage as a powerful cryoprotective agent.

The therapeutic potential of various substances and extracts dissolved in DMSO has thus been the subject of numerous investigations. Other research has directly evaluated how DMSO affects different disease situations.

History of DMSO IV Therapy

DMSO has its beginnings in the developing German chemical industry of the mid- to late 19th century, like so many modern pharmaceuticals. A procedure was created in the search for less expensive, more effective ways to make paper from wood pulp, and some of its by-products contained sulphides. These offensive sulphides were changed into less offensive sulfoxides, including DMSO.

This colorless liquid was used right away as a polar, aprotic solvent that was water miscible and capable of dissolving a vast array of polar and nonpolar tiny molecules. Chemical literature has examined DMSO extensively since the 1860s. It has both hard and soft nucleophile characteristics and is a favored solvent for a variety of specified reactions. The study of carbanion chemistry has greatly benefited from its regular usage as a moderate oxidant in a number of synthetic schemes. In addition to this revolutionary reaction chemistry, it was quickly discovered that DMSO possessed the extremely rare capacity to “transport” tiny molecules across a range of obstacles.

The systematic exploration of DMSO as a transport agent that may be utilized to transfer tiny molecules via skin and mucosa resulted from the observation that DMSO spilled into the hands would immediately result in a noticeable garlic taste on the tongue. Three functional categories—tissue/organ preservation, penetration-enhancing solvent excipients, and active pharmacological agents, especially anti-inflammatory—comprise the majority of DMSO’s medical applications.

Dr. Stanley Jacob’s early 1960s study on organ preservation paved the way for pharmacotherapeutic studies by both his lab and a plethora of other research organizations. The therapeutic history has received substantial review in both scholarly and popular literature, and it is debatable to say the least. DMSO has been the subject of more than 1,200 articles, but it lost appeal in the 1960s as a result of the FDA’s increased rigour following the finding of limb deformities in offspring born to women who took thalidomide.

The FDA ultimately authorized a 50% DMSO solution for intravesicular administration in 1978 for the treatment of interstitial cystitis under the trade name Rimso-50. This is still the only approved human indication, aside from the generic version authorized in 2002. Many veterinary DMSO treatments, both by itself and in conjunction with steroids, have been FDA-approved and are currently offered under a number of brand names, including Domoso, Domoso Gel, Synsac, and Synotoc Otic.

Jacob initially saw that DMSO successfully penetrates the skin in a series of nine patients who were being treated for dermatitis with topical DMSO. Actually, he had to make this discovery again because it had been previously reported in the German chemical literature as detailed above.

As a result, there was a flurry of effort evaluating the efficacy for various dermatological disorders, with varying findings due to the insufficient understanding of the mechanisms. Most of these older investigations emphasized the local rather than systemic delivery of anti-inflammatory effects.

Both subjectively and objectively, cutaneous scleroderma showed potential promise. Topical treatment was used several times per day for several weeks to dramatically speed up the healing of ischemic ulcers on the fingertips.

Patients with scleroderma also reported enhanced range of motion due to increased skin elasticity and less pain. After several months of treatment, keloids and hypertrophic scars demonstrated flattening, suggesting clinical value in dermis-related illnesses and disorders.

Early in the 1960s, when the potential for this unique function started to become apparent, systematic studies of small molecule transport through the skin using DMSO as a carrier also got underway.

Mechanisms of Action for DMSO IV Therapy

Dimethyl sulfoxide’s activities are not fully understood at this time. In certain biological environments, dimethyl sulfoxide has proven to have antioxidant properties. For instance, it is believed that an antioxidant mechanism is responsible for dimethyl sulfoxide’s cardiovascular protective action in copper-deficient rats.

Additionally, it is believed that dimethyl sulfoxide’s potential anti-inflammatory properties are a result of its antioxidant activity. An industrial solvent, dimethyl sulfoxide (DMSO), is a by-product of the lumber industry.

Early in the 1960s, DMSO was used for the first time as a therapeutic agent to treat interstitial cystitis and arthritis290. Since then, DMSO has been widely used in the equine industry alone or in combination with corticosteroids to lessen soft tissue swelling, inflammation, and edoema brought on by acute trauma.

Both DMSO and its metabolite, dimethyl sulphide, have a variety of pharmacological effects. There is evidence that DMSO contains superoxide dismutase action. As a result, DMSO can inhibit the hydroxyl radical’s role in the depolymerization of hyaluronan, inactivate superoxide radicals, and prevent the production of PG by oxygen-derived free radicals. Because prostaglandins E2, F2, H2, and G2 are inhibited by DMSO, it is thought to have analgesic characteristics.

Both acute and chronic musculoskeletal pain can be effectively treated with DMSO’s analgesic effect, which has been comparable to that of narcotic analgesics. In spite of not having the same effect as corticosteroids in terms of absorption, DMSO has an anti-arthritic effect. In a horse synovitis model, topical administration of the DMSO gel formulation reduced the mean synovial white blood cell concentrations.

Through improved blood flow and vascular dilatation, DMSO has been demonstrated to aid in the resolution of tissue inflammation. Collagen is dissolved by DMSO, which may aid in regaining the pliability of fibrosed tissues.

When used to treat acute inflammation as opposed to chronic inflammation, DMSO appears to have greater anti-inflammatory and anti-arthritic benefits. Topical use of DMSO solution reduced ankle stiffness in a fracture model of arthritis in rabbits.

After being administered orally, intravenously, or topically, dimethyl sulphide and DMSO are both swiftly and extensively transported to every part of the body. The parent compound’s and its metabolite’s half-life is nine hours.

Although DMSO is primarily eliminated through the kidney, it can also be eliminated by the respiratory system and bile.

Animals and humans may easily absorb DMSO through oral and dermal channels, and it increases the absorption of many other compounds through those routes. In comparison to more diluted DMSO solutions in water, higher quantities of DMSO are more easily absorbed.

Within 5 minutes of topical application, radiolabeled DMSO and halitosis caused by the metabolite dimethyl sulphide were both found in the blood. It has been claimed that distribution to other organs happens in under 20 minutes. Within one-hour, radiolabeled DMSO was found in animal bones and teeth.

Due to its facilitation of the absorption of numerous other chemicals via biological membranes, DMSO can disrupt ionic equilibrium. In people, dimethyl sulfone and dimethyl sulphide are the two main metabolites of DMSO.

Following oral administration, roughly two-thirds of the dose are eliminated in the urine as unmodified DMSO, about twenty percent are excreted as dimethyl sulfone, and five percent are exhaled as dimethyl sulphide.

Additionally, these metabolites have been found in rats and monkeys. The cornea of the eye appears to accumulate the highest quantities, and the lens, the lowest. Dimethyl sulfone has a half-life of 38 hours in blood compared to 16 hours for DMSO.

In humans, about 3% of oral doses result in dimethyl sulphide exhalation; in animals, the percentage seems to be a little greater. After one dose, DMSO can remain in serum for more than two weeks.

How DMSO IV Therapy is Used to Treat Medical Conditions

1. Blood coagulation may be slowed by DMSO. The likelihood of bleeding and bruising may rise if DMSO is combined with drugs that help impair coagulation.
2. Aspirin, cilostazol (Pletal), clopidogrel (Plavix), ibuprofen (Advil, Motrin, others), naproxen (Anaprox, Naprosyn, etc.), dalteparin (Fragmin), enoxaparin (Lovenox), heparin, ticlopidine (Ticlid), warfarin (Coumadin), and other drugs are examples.
3. Intravenous DMSO may help treat amyloidosis, according to a small number of clinical trials, presumably by causing amyloid deposits to be mobilized from tissues and excreted in urine.
4. When used topically, DMSO appears to offer individuals with arthritis and connective tissue injuries quick, brief pain relief. However, there is currently little evidence to support claims of anti-inflammatory properties or faster healing.
5. In experimental animals, intravenous DMSO is equally effective in treating cerebral edoema and intracranial hypertension as mannitol and dexamethasone. This latter application is generally supported by an initial clinical investigation including 11 participants.
6. Idoxuridine and DMSO mixes are applied topically to treat herpes zoster in the UK because DMSO improves the diffusion of other drugs through the skin.
7. An FDA-approved medication called DMSO is used to treat interstitial cystitis, a bladder ailment. Interstitial cystitis symptoms like discomfort are improved by washing the bladder with DMSO.
8. Complex regional pain syndrome-related discomfort. According to research, complicated regional pain syndrome sufferers with pain can feel less discomfort after applying DMSO 50% cream on their skin.
9. Chemotherapy can harm skin and tissue if it escapes from the IV. Some chemotherapy medications have the potential to damage skin and tissue if they leak from the vein into the skin or the tissue around it. If this occurs, research suggests that using DMSO to the skin could perhaps stop additional harm.
10. Shingles (herpes zoster) (herpes zoster). According to research, DMSO applied topically in combination with the medication idoxuridine lessens shingles-related lesions and swelling.
11. Inflammation of the bladder. According to research, DMSO bladder washing helps persons with chronic inflammatory bladder disease feel better.
12. Suffering with shingles. According to research, DMSO applied topically in combination with the medication idoxuridine eases shingles pain. The name of this condition is post-herpetic neuralgia.
13. An ailment known as amyloidosis. According to some preliminary study, DMSO can be used to treat amyloidosis by washing the bladder, applying DMSO to the skin, or ingesting it orally.
14. Bile duct stones When injected into the bile duct with specific other solutions, preliminary study indicated that DMSO might help dissolve bile duct stones.
15. Agony brought on by cancer. According to preliminary study, administering sodium bicarbonate and DMSO intravenously (IV) may enhance the quality of life for those with cancer-related discomfort.
16. Ulceration on the feet caused by diabetes. According to preliminary studies, DMSO application to the damaged area may hasten the healing of diabetic patients’ foot ulcers.
17. Cerebral blood pressure that is too high. According to some data, intravenously administered DMSO may reduce excessive blood pressure inside the brain (by IV).
18. Arthritis. According to preliminary study, skin application of DMSO may help lessen osteoarthritis or rheumatoid arthritis symptoms (RA).
19. Abdominal ulcers According to preliminary studies, DMSO may be more successful than the pharmaceutical cimetidine for treating ulcers in persons who have Helicobacter pylori-caused ulcers or ulcers that haven’t responded to prior treatments.
20. A pressure sore. Early research indicates that massage and the application of DMSO 5% cream to the skin do not prevent pressure ulcers in nursing home residents.
21. Aiding skin recovery following surgery. According to preliminary study, administering DMSO to the skin may aid in the healing of wounds.
22. Tendon damage (tendinopathy). According to preliminary study, persons with tendon injuries may have less discomfort and better joint movement after administering DMSO 10% gel to the skin.

Intravenous IV DMSO vs Oral Supplementation

A pharmaceutical drug and nutritional supplement, DMSO. It can be ingested, administered topically to the skin, or injected into the veins (used intravenously or by IV).

DMSO is administered intravenously, topically, or orally to treat amyloidosis and its symptoms. A disorder known as amyloidosis causes aberrant protein deposition in organs and tissues.

• 77-90% DMSO is commonly applied under medical supervision every 3–8 hours for 10–14 days to prevent some negative effects of cancer treatment.
• For shingles (herpes zoster), apply 5–40% idoxuridine in DMSO every four hours for four days, starting 48 hours after the rash first appears.
• For up to three weeks, a 50% DMSO solution was applied four times per day to treat nerve discomfort.
• 25% DMSO gel and 45.5% DMSO topical solution have both been used three times daily for osteoarthritis.
• Using a catheter, medical professionals drip a DMSO solution into the bladder to treat chronic inflammatory bladder disease and the frequent urge to urinate caused by interstitial cystitis. The patient is asked to retain the solution for a while before peeing when the catheter is removed.
• Given intravenously, dimethyl sulfoxide (DMSO) has anti-inflammatory and free radical scavenging properties. The ideal way to provide DMSO (90% solution), polyionic solutions, and 5% dextrose is slowly, at a rate of roughly 8 L/h. For the risk of intravascular hemolysis to be minimized, the DMSO concentration must be kept below 20%. DMSO may be valuable, but thus far, it hasn’t lived up to its potential as a laminitis treatment. There is proof that the aetiology of laminitis in horses brought on by black walnut extract does not require ischemia, reperfusion damage, or the production of free radicals.
• Dimethyl sulfoxide, or DMSO, may enhance the absorption of medication by your body. The amount of medicine your body absorbs may be increased if you take DMSO along with oral drugs. Your medication’s effects and negative effects may become more pronounced if you increase the amount of drug your body absorbs.
• DMSO is administered intravenously, topically, or orally to treat amyloidosis and its symptoms. A disorder known as amyloidosis causes aberrant protein deposition in organs and tissues.
• DMSO is applied topically to wounds, burns, and muscular and skeletal injuries to lessen discomfort and hasten healing. Additionally, DMSO is applied topically to treat excruciating illnesses like headache, inflammation, osteoarthritis, rheumatoid arthritis, and tic douloureux, a severe form of face agony. It is applied topically for conditions affecting the eyes, such as cataracts, glaucoma, and issues with the retina, as well as for conditions affecting the feet, such as bunions, calluses, and toenail fungus. When chemotherapy escapes from the IV used to give it, it is occasionally applied topically to repair skin and tissue damage. DMSO is used to relieve shingles pain either by itself or in conjunction with a medication called idoxuridine (herpes zoster infection).
• DMSO is used intravenously to reduce the brain’s unusually high blood pressure. Additionally, it is used intravenously to treat interstitial cystitis, a bladder infection, and chronic inflammatory bladder disease. Certain DMSO products have received FDA approval for use in the bladder to treat the signs and symptoms of chronic inflammatory bladder disease. To treat bile duct stones, DMSO is occasionally injected along with other drugs into the bile ducts.
• DMSO is employed in production as an industrial solvent for antibiotics, plant hormones, fungicides, and herbicides.

Molecular Formula of DMSO IV

Dimethyl sulfoxide, a 2-carbon sulfoxide, having two methyl substituents on the Sulphur atom. As a polar aprotic solvent, radical scavenger, non-narcotic analgesic, antidote, MRI contrast agent, Escherichia coli metabolite, geroprotector, and alkylating agent, it also serves as a variety of other functions. It is a volatile chemical molecule and a sulfoxide.

Its molecular formula is C2H6OS or (CH3)2SO and molecular weight is 78.14. Its IUPAC name is methylsulfinylmethane.