This page explains Glutathione IV Therapy including its benefits. IV Therapy provides Glutathione IV Therapy.
Your liver generates glutathione, a potent and advantageous antioxidant, and a tripeptide, in your body. Glycine, glutamine, and cysteine are the three amino acids that make up this tripeptide.
A chemical group of sulphur that is sticky makes up glutathione. This group gathers all the dangerous molecules (free radicals) that are roving around in your body in order to destroy them.
Your body uses extra energy to rebuild the immune system after removing these free radicals.
“Glutathione is a substance made from the amino acids glycine, cysteine, and glutamic acid. It is produced by the liver and involved in many body processes.” — WebMD
Glutathione can be found in a variety of meals, oral supplements, and liquid forms. Glutathione taken orally, however, is insufficient for your body to stay in equilibrium. It only covers fifty percent of the glutathione. However, your body can absorb 90–100% of the glutathione content when you get glutathione drip intravenously. Glutathione not only strengthens your immune system but also helps you detoxify.
By making melanin lighter in tone, it also induces skin whitening. Additionally, it stops the pigment-causing enzyme tyrosinase from working. Your glutathione level may drop as you get older and deal with different medical conditions. However, you can balance your body’s glutathione levels using glutathione IV therapy.
Injecting glutathione into your body is done through glutathione IV treatment. Bypassing the gastrointestinal tract with this efficient treatment, your doctor can provide healthy nutrients directly to your bloodstream. Maximum gain is ensured because they do not have a breakdown en-route.
Treatments with glutathione intravenous last only 15 to 20 minutes. All you have to do is use your phone while relaxed in a chair. After that, you can get back to your regular schedule.
Benefits of Glutathione IV
There is a potent package of advantages to glutathione IV infusion therapy for your body and skin. You will realize why it is dubbed the Master Molecule once you have it and experience how it makes you feel. These are but a few of the advantages:
- Detoxification
According to The Fork Functional Medicine Clinic, our livers are the most important organ to focus on when detoxing. This is partially attributed to the nutrient’s ability to reduce free radicals in our systems. Giving patients with fatty liver disease high-dose glutathione IVs led to successful outcomes in one trial. These trial findings demonstrate the efficacy of their intravenous, high-dose therapeutic strategy. Please take note that there may be health concerns when using large amounts of any antioxidant supplement, thus we advise visiting a doctor before doing so.
- Enhances Athletic Capability
Glutathione is one of the top nutrients for reaching your sports optimum performance. In addition to lowering instances of muscle damage, it also increases strength and endurance, motivates your body to produce more muscle than fat, and speeds up recovery.
- Prevention of Chronic Illness
Everyone who has a chronic condition of some kind, such as Parkinson’s disease, heart disease, chronic fatigue syndrome, arthritis, or cancer, have one thing in common: They have low glutathione levels. We become ill when our bodies have accumulated too many poisons or are under excessive oxidative stress. Toxins and stress are eliminated by glutathione using its antioxidant abilities, which helps to prevent chronic sickness.
- Inflammation
Free radicals love to assemble in your body, inflaming and harming their chosen meeting place. However, when glutathione levels are enough, the antioxidant disrupts the free radical celebration, which means inflammation is no longer a problem because the cell-damaging chemicals that were the source of it have been ejected.
- Aging Process Slowed Down
The ageing process is sped up by damaged cells, which glutathione spends a lot of time mending. By eliminating free radicals from our systems, we’re bringing in tighter, more youthful skin, stronger hair and nails, and more vitality. Additionally, glutathione promotes mitochondrial development, resulting in younger, healthier cells to replace the older ones.
- Suitable For Rather Most Ages
Almost anyone’s biology can benefit from glutathione IV therapy when it is administered by a qualified medical specialist (parental consent is advisable for minors).
History of Glutathione IV
The most prevalent naturally occurring non-protein thiol that shields human cells from oxidative stress is glutathione (GSH). J. de Rey-Paihade first identified glutathione in 1888 while studying extracts of yeast, numerous animal tissues, including fresh egg white, lamb small intestine, lamb brain, and fish skeletal muscle. This chemical was given the name philothion by de Rey-Paihade, which is Greek for “love and sulphur.” Hopkins proposed in 1921 that the philothion isolated from liver, skeletal muscle, and yeast is a dipeptide composed of cysteine and glutamate, but these writers failed to mention the existence of glycine in philothion, maybe as a result of a misunderstanding of the Van Slyke amino N data.
Hopkins gave the material the name “glutathione” in remembrance of the philothion’s history of discovery. Hunter and Eagles suggested in 1927 that glutathione is not a dipeptide comprising glutamate-cysteine but rather a tripeptide consisting of glutamate-cysteine plus a second low-molecular-weight amino acid based on the nitrogen and sulphur content in glutathione isolated from yeast, blood, and liver (possibly serine). Hopkins proposed that glutathione is a tripeptide made of cysteine, glutamate, and glycine in 1929 using an acid hydrolysate of glutathione.
The independent research done in 1929 and 1930 by Kendall and colleagues validated this proposition. Pirie and Pinhey stated in 1929 that the structure of glutathione is glutamate-cysteine-glycine based on the titration of glutathione in water and formaldehyde as well as the measured pK values. In 1935, Harington and Mead used the chemical synthesis of N-carbobenzoxycystine and glycine ethyl ester to validate the structure of glutathione. A year later, du Vigneaud and Miller produced glutathione again chemically by combining S-benzylcysteinylglycine methyl ester with the acid chloride of N-carbobenzoxyglutamate-methyl ester. Over the past 50 years, glutathione has been discovered in every cell. Related chemicals that have been discovered so far include (y-Glu-Cys)n-Gly in plants and y-Glu-Cys-Gly-spermidine in E. coli.
Chemist Vincent du Vigneaud of Cornell Medical College (now Weill Cornell Medicine), in New York City, is credited with creating glutathione for the first time in 1952. Du Vigneaud was a recipient of a Nobel Prize in Chemistry in 1955 for his research on physiologically significant sulphur compounds. In a study published in April, glutathione was found to increase T cell energy metabolism in addition to serving as an antioxidant, according to Dirk Brenner of the Luxembourg Institute of Health and coauthors from seven other nations. T cells are stimulated, which enables them to produce the best immune response and ward against infections. New treatments for autoimmune disorders and cancer could result from this discovery.
What Are The Mechanisms Of Action For Glutathione IV?
Glutathione’s value cannot be overstated. Protecting cellular macromolecules against endogenous and external reactive oxygen and nitrogen species is one of its key functions. While some free radicals are quenched immediately, dealing with the root sources of oxidative stress like mercury and POPs is perhaps more significant. Both xenobiotic and endogenous chemicals are detoxified by glutathione. It enhances excretion from the body (POPs, Hg), from cells (Hg), and directly neutralizes (POPs, many oxidative chemicals). At least four separate pathways, including the production of glutathione S-conjugates, which is the most crucial mechanism, allow glutathione to enhance the transport of toxins across the plasma membrane.
Leukotriene production is aided by glutathione (GSH), which also functions as a cofactor for the enzyme glutathione peroxidase. It functions as a hydrophilic molecule that is attached to other lipophilic toxins or wastes before they enter biliary excretion, which is another function it performs in the hepatic biotransformation and detoxification process. It takes part in the glyoxalase-mediated detoxification of the hazardous metabolic byproduct methylglyoxal. Methylglyoxal and reduced glutathione are transformed into S-D-Lactoyl-glutathione by the enzyme glyoxalase I. S-D-Lactoyl Glutathione is converted to Reduced Glutathione and D-lactate by Glyoxalase II. Methylglyoxal and reduced glutathione are transformed into S-D-Lactoyl-glutathione by the enzyme glyoxalase I. S-D-Lactoyl Glutathione is converted to Reduced Glutathione and D-lactate by Glyoxalase II. Glutathione S-transferase enzymes are expressed in the cytosol, microsomes, and mitochondria and catalyze conjugation and reduction reactions. GSH is a cofactor in these processes.
It can, however, engage in non-enzymatic conjugation with some substances, as it is predicted to do to a substantial amount with n-acetyl-p-benzoquinone imine (NAPQI), the reactive cytochrome P450 reactive metabolite produced by acute acetaminophen overdose. In this capacity, glutathione binds to NAPQI as a suicide substrate and detoxifies it by substituting cellular protein sulfhydryl groups for those that would otherwise be toxically adducted. N-acetylcysteine injection (often in atomized form), which is used by cells to replenish used GSSG and enable a usable GSH pool, is the chosen medical treatment for an overdose of this kind, and its efficacy has been repeatedly confirmed in literature.
How Is Glutathione IV Used To Treat Illness And Aging?
Free radical buildup over time might hasten the ageing process in your body. A higher concentration of free radicals may result in increased cell damage, which could speed up the ageing process by causing wrinkles, dull skin, and decreased energy. Glutathione can reduce the ageing process and help you maintain a youthful and radiant appearance by removing free radicals before they can accumulate and cause cellular harm. Damage to mitochondria can contribute to the onset of disease, same way free radicals and ageing do. IV glutathione supports proper mitochondrial development, which helps fight sickness at the cellular level.
How Is Glutathione IV Used To Treat Nerve Damage?
Drug Cisplatin causes damage to the nerves. By administering glutathione intravenously, the cancer treatment cisplatin appears to be less likely to cause nerve damage and other toxicities. It should be noted that only medical professionals are authorized to administer IV products.
How Is Glutathione IV Used To Treat Parkinson’s disease?
A strong, naturally occurring intracellular antioxidant is glutathione. In patients with early Parkinson’s disease, the substantia nigra’s glutathione levels are markedly decreased. In a modest open label study, glutathione was tried as a twice-daily intravenous infusion. A more recent double-blinded study of three intravenous infusions per week showed an early good trend but a worsening of symptoms when the treatment was stopped. Bastyr University is conducting a phase II clinical trial of an intranasal glutathione delivery method that circumvents the blood-brain barrier. Glutathione treatment for Parkinson’s disease is currently being debated due to a lack of sufficient proof. As a precursor to glutathione, N-acetyl cysteine can help restore glutathione levels that have been depleted as a result of reactive oxygen species, which are involved in the pathophysiology of Parkinson’s disease.
How Is Glutathione IV Used To Treat Heart Diseases?
Immediately before and after primary angioplasty (primary percutaneous coronary intervention), glutathione administration may be beneficial in regulating immune cell activation and limiting infarct growth. Early and persistent glutathione infusion appears to be able to shield essential endothelial cell function and myocardial components from detrimental pro-oxidant and inflammatory conditions, hence inhibiting maladaptive cardiac repair and unfavorable left ventricular remodeling.
How Is Glutathione IV Used To Treat Cancer?
Glutathione metabolism can have both preventive and harmful effects with regard to cancer. It is essential for the detoxification and elimination of carcinogens, and changes to this route can have a significant impact on cell survival. Elevated levels of glutathione in tumor cells are able to protect such cells in bone marrow, breast, colon, throat, and lung malignancies, though, by conferring resistance to a number of chemotherapeutic medicines.
Intravenous Glutathione IV vs. Oral Supplementation
Intravenous – Glutathione can be given as a drip or a push. The nutrients can be delivered to your cells in a variety of ways, including a glutathione push and a drip. Food sources of glutathione are difficult to digest; however, IV drips and pushes avoid the gut, where many nutrients are lost when consumed orally, and are administered directly to the circulation, where they can be utilized by your cells.
IV Push is delivery of the nutrients via syringe. Characteristics of this method are:
- A push can be finished in 20 minutes since it is not that much diluted;
- It costs less than a drip if the patient does not want supplementary vitamins and nutrients added.
IV Drip is delivery of the nutrients via drip. Characteristics of this method are:
- A patient gets some relaxation time during their treatment since a drip takes about 45 minutes because it is more diluted (saline);
- A choice of addition of extra nutrients is provided with a drip;
- Patient can decide for a higher dose of vitamin C as it will be more diluted and less caustic.
Oral – Stomach acids dissolve the peptide links that hold the amino acids in oral glutathione together, rendering it inactive. The best approach to get this potent antioxidant into the bloodstream and into the body’s cells is through a glutathione IV.
Molecular Structure of Glutathione IV
- The molecular structure of Glutathione is γ-Glutamate–Cysteine–Glycine. It IUPAC name is (2S)-2-Amino-5-({(2R)-1-[(carboxymethyl)amino]-1-oxo-3-sulfanyl-2-propanyl}amino)-5-oxopentanoic acid.
- Its Molecular Weight is 307.33 and Molecular Formula is C10H17N3O6S
- In cells, glutathione can be found in two states: reduced (GSH) and oxidized (GSSG). Figure given below illustrates how two reduced glutathiones are joined at the sulphur atoms to form the oxidized glutathione.
