The following guide explains IV Taurine Benefits.
What Is IV Taurine?
In mammals, taurine, a sulfur-containing amino acid that is mostly generated by the liver and kidney, is considered to be semi-essential. It occurs in various organs, including the placenta, brain, heart, and retina, and it exhibits intense physiological activity throughout the body.
IV Taurine can also lessen damage brought on by oxidative stress and inflammation in a variety of disease scenarios. Larger activities of Taurine include molecularly regulating ER stress, Ca2+ homeostasis, and neuronal activity.
Fast-acting amino acid taurine is present in many meals and is frequently added to energy and fizzy beverages. Taurine, sometimes known as the “wonder molecule” as well, is a crucial nutrient that functions as an antioxidant and a natural energy booster. IV Taurine can alleviate hangover-related fatigue, oxidative stress, and blood toxicity to help the body feel balanced once more, in addition to a range of other health advantages.
IV Taurine can be consumed up to 6000 mg per day, however the typical diet only provides 40–400 mg. Cattle, fish, and dairy items contain taurine generally. Some processed vegetarian and vegan meals may include it, but since it doesn’t occur naturally in these foods, people who regularly consume them will probably need to take additional taurine pills to obtain the recommended daily dose.
Studies overwhelmingly indicate that IV taurine supplementation, even when taken on temporary basis, may support improved physical function, reduce the cardiovascular dangers that can arise after exercise, and alleviate problems related to the failure of heart.
In a University of Stirling’s research, middle distance runners were assessed both before and after taking extra taurine. The athletes took 1,000 milligrammes of taurine two hours before exercising, and their heart rates, blood lactate levels, and respiratory systems were all examined to make sure there was no negative impact. 90% of the runners then displayed faster times. This study indicates that there is a 99.3% possibility that taurine played a role in the athletes’ enhanced time trial performance.
Thus, Taurine has diverse beneficial effects which are discussed in the next section.
IV Taurine Benefits
IV Taurine has numerous benefits apart from alleviating symptoms of depression:
- Strengthens heart function: By bringing down blood pressure and soothing the neurological system, it might help those with a chance of heart failure. It might also help stop the progression of heart failure.
- Boosts energy levels and mental focus: Taurine can perform as an antioxidant to heal impaired cells and lessens oxidized stress on muscles.
- Helps bolster vision and prevent macular degeneration: In vitro, taurine greatly increased RGC survival (+68%) and mitigated the excitotoxicity caused by NMDA on RGCs. Additionally, it’s been suggested that taurine supplementation may be a protective and effective treatment for retinopathies with a chronic cycle, such as retinitis pigmentosa, an inherited condition marked by a gradual deterioration of rod photoreceptors.
- Improves athletic performance: Taurine improves exercise performance for both athletes and individuals trying to get in shape by lowering fatigue, boosting stamina, and enabling your muscles to work harder for a longer period of time.
- Aids in treatment of anxiety: IV Taurine acts on the same receptors in the brain as glycine and GABA to encourage muscle relaxation, reduce anxiety, aid in secreting growth hormone, stimulate sleep, and promote relaxation.
- Protects the brain: IV Taurine administration can control a number of cellular functions, including protein quality control, osmosis, gene expression, and energy metabolism. Taurine also exhibits potential ameliorating effects against a variety of neurological conditions, including diabetic neuropathy, stroke, epilepsy, and neurodegenerative illnesses, in addition to safeguarding the nervous system from toxins and damage.
- Aids in treatment of epilepsy: Epileptic symptoms are hypothesized to be caused by dysfunction of excitatory and inhibitory neurotransmitters or neuromodulators. The majority of animal species, including humans, contain large amounts of the free amino acid taurine in their brains. Taurine administration helps neurons to become hyperpolarized, which prevent them from firing.
- Condenses triglycerides to prevent obesity.
- Lowers cholesterol and blood pressure: It prevents cardiovascular disease by reducing cholesterol levels and lowering blood pressure.
History Of IV Taurine
In 1827, two German scientists named Friedrich Tiedemann and Leopold Gmelin successfully extracted it from ox bile. In reference to this, the Latin word Taurus, which means bull or ox, gave rise to the name taurine. Taurine was found in muscle tissue and animal bile during the ensuing decades, including human bile in 1846, according to investigations. The amount of taurine in plants does not seem to be as high as in animals.
A “conditionally” necessary amino acid, taurine is not involved in the production of proteins. However, considering its substantial significance in a variety of biological processes, such as bile salt production, osmoregulation, antioxidant defense, retinal development, and the cardiovascular and central neurological systems, its existence in the body seems to be absolutely necessary.
Taurine also activates the inhibitory GABA receptors in the brain. This suggests that certain brain circuits are inhibited by taurine, maintaining the stimulation-inducing effects of other drugs like coffee. Scientists started researching taurine’s potential medical applications, which were made possible in part by the fact that cats cannot generate taurine and suffer severely when it is not present in their diet.
A plentiful -amino acid with a variety of cytoprotective properties is taurine. IV Taurine is an essential nutrient in several species. It is regarded as a semi-essential nutrient in humans, despite the fact that cells missing taurine exhibit severe disease. These results have sparked curiosity in taurine’s potential as a medication. The investigation of IV taurine as a therapeutic agent against other illness states was sparked by the revelation that it is a successful treatment for congestive heart failure. Currently, taurine is approved in Japan for the treatment of congestive heart failure and has positive clinical results for a number of other disorders.
What Are The Mechanisms of Action for IV Taurine?
Taurine’s physiochemical characteristics may make it a perfect modulator of a number of fundamental processes, such as osmoregulation, modulation of protein phosphorylation, calcium ion regulation, anti-oxidant response, membrane stabilization, bile acid conjugation, lipid metabolism, and glucose regulation.
IV Taurine protects from sickness and pathology. Most cells contain high taurine concentrations, which control the physiological operation of excitable tissues and mitochondria. By reducing ER stress and blocking the GABAA, glycine, and NMDA neurotransmitter receptors, taurine protects the central nervous system (CNS).
Taurine IV defends the cardiovascular system by controlling cellular signaling, including Ca2+ transport, ROS production, and protein phosphorylation. Taurine supplementation reduces MELAS and diabetic mellitus symptoms. In inflammatory conditions like rheumatoid arthritis and osteoarthritis, taurine either inhibits the production of nitric oxide and prostaglandin E2 or causes neutrophils to produce taurochloramine.
Dysfunction in the heart and skeletal muscles is caused by taurine depletion or taurine transporter KO. Taurine slows down the gradual loss of muscle, preventing sarcopenia in older people.
Taurine IV is said to occupy more than 50% of total free amino acid pool in the heart. It appears to have a beneficial inotropic effect on cardiac tissue and in lowering high blood pressure. Due to its control over the voltage-dependent calcium and sodium channel function, taurine shields cardiomyocytes from harm brought on by either excessive or insufficient levels of calcium ion.
Taurine has a broad range of effects on ion channels and transporters at the same time, despite the fact that its exact method of action is unclear. Additionally, it has been proposed that taurine stabilizes membrane potential by interfering with Na+K+ATPase that is membrane-bound.
Through changes in calcium homeostasis, taurine IV has been demonstrated to molecularly counteract the oxidative stress brought on by vigorous exercise in young men. Contractile filaments become more susceptible to intracellular calcium levels as a result of this mechanism of action, which is based on raising intracellular calcium levels released from the SR (179).
Increased muscle strength and decreased muscle soreness are other results of taurine supplementation’s beneficial effects on calcium homeostasis after strenuous exercise. Serum LDH activity, creatine kinase activity, PC content, and LPO are also reduced as a result.
How Is IV Taurine Used To Treat Retinal Degenerative Disorders?
With more taurine than any other amino acid, the retina is the body’s most taurine-rich organ. Taurine IV is a potential treatment candidate since oxidative stress is a significant contributor to retinal degenerative disorders.
Investigation into the connections between taurine and retinal illness was driven by the finding that the anti-epileptic medication vigabatrin led to taurine depletion and retinal degeneration. Diabetes retinopathy has been associated with low levels of taurine in the plasma of diabetic patients.
How Is IV Taurine Used To Treat Neurological Disorders?
Taurine IV has a role in the proliferation of neural stem or progenitor cells in the developing brain, which is a process that may be linked to the formation of synapses by extracellular signal-regulated kinase (ERK)1/2 pathways. Protein levels such as synapsin 1 and postsynaptic density protein-95, which are essential for the formation of synapses, are influenced by taurine.
Several research have discussed taurine’s anti-neuroinflammatory properties. After induced traumatic brain injury, taurine dramatically improved functional recovery and reduced glial fibrillary acidic protein buildup and water content in the penumbral area (TBI). In comparison to the TBI group, it dramatically reduced the levels of growth-related oncogene and interleukin (IL)-1 while increasing the levels of regulated on activation, normal T cell-expressed and -secreted (RANTES).
How Is IV Taurine Used To Treat Diabetes?
Numerous studies have been conducted on taurine’s function in the development, prevention, and management of diabetes. There is evidence that taurine supplementation can help prevent type 1 diabetes, type 2 diabetes mellitus, metabolic syndrome, as well as certain frequent problems associated with diabetes.
How Is IV Taurine Used To Treat Pathogenic Infections?
The conversion of cholesterol into bile acids is taurine’s major job. Bile salts, which combine with phospholipids and cholesterol to produce mixed micelles, are created by conjugating bile acids with taurine or glycine at a ratio of about 1:3. To facilitate digestion and nutritional absorption, they are secreted from the gallbladder where they are stored.
The microbiome has been proven to be protected by taurine, which may help reduce the overuse of antibiotics. According to one study, taurine levels have an impact on the colonization of the gut by pathogens, and a minor infection can cause the liver and gallbladder to use taurine-conjugated bile acids to improve the microbiome and increase resistance to secondary infections. This has fascinating ramifications for therapies based on the microbiome.
How Is IV Taurine Used To Treat Renal Dysfunction?
Numerous kidney diseases, including renal failure, acute kidney injury, glomerulonephritis, and diabetic nephropathy, have been linked to taurine. Similar to diabetes, the majority of research has been done using animal models, but taurine’s proven involvement in controlling oxidative stress, blood flow, and cell volume points to a protective impact.
Intravenous IV Taurine vs. Oral Supplementation
Taurine IV can be administered via two forms. These forms are:
- Taurine injections are the intravenous form of administration. Their strength may vary depending upon the circumstances.
- Taurine IV can be taken orally from three types of sources:
Supplements – Between 500 and 2,000 mg of taurine per day is the most typical dosage for dietary supplements. Although the maximum tolerable dose is substantially higher, doses greater than 2,000 mg appear to be well tolerated. 400 to 6,000 mg per day were utilized in studies with dietary supplements.
Energy Drinks – The amount of taurine in a 235 ml serving of soda and energy drinks can range from 600 to 1000 mg. However, it is not advised to consume sodas or energy drinks due to additional dangerous elements.
Food – Since taurine is mostly found in animal products like meat, fish, and dairy products, a balanced diet is probably the best way to ensure that you are getting the recommended amount. It can be used as a supplement to baby foods manufactured without milk and also appears in dairy-based baby foods. Healthy humans may produce taurine from sulfur-containing amino acids like cysteine and methionine, according to the FDA. Taurine is a semi-essential nutrient as a result. However, dietary supplements may be necessary for babies and those who are at specific phases of the disease.
IV Taurine intake for those who consume both plant-based and animal products has been calculated to range from 9 to 400 mg per day. The estimated daily intake for ovo-lacto vegetarians is 17 mg, whereas taurine is completely absent from vegan diets. According to the FDA, those who consume little taurine can maintain taurine levels. Basically, if taurine is only consumed in little amounts, as is the case with a vegetarian or vegan diet, the excretion of taurine through the urine is low.
Taurine quantity present in certain food:
Meat and Poultry – 11 to 306 milligrams per 100 grams
Seafood – 11 to 827 mg per 100 grams
Dairy Products – 2 to 8 mg per 100 ml
Breast Milk and Infant Formula – 4 to 7 mg per 100 ml
Molecular Structure of IV Taurine
Molecular Formula of Taurine is 2-aminoethanesulfonic acid or NH2CH2CH2SO3H or C2H7NO3S.
Further details of Taurine include:
Name – Taurine
UIPAC Name – 2-Aminoethane-1-sulfonic acid
Formula – NH2CH2CH2SO3H or C2H7NO3S
Molecular Weight – 125.15
CAS – 107-35-7
HMDB – HMDB0000251
ChEBI – 15891