This page covers Methylene Blue IV Therapy including its benefits. IV League offers mobile IV therapy for Methylene Blue.
The salt methylthioninium chloride, also known as methylene blue, is employed as a medicine and a color. A thiazine dye is methylene blue. By changing the ferric iron in hemoglobin to ferrous iron, it mostly treats methemoglobinemia.
It is used to treat patients with methemoglobin levels greater than 30% or who continue to experience symptoms despite receiving oxygen therapy. Prior to now, it was advised against using it to treat urinary tract infections and cyanide poisoning.
Methylene Blue an organic chloride salt. An everyday dye with anti-inflammatory, anti-malarial, antidepressant, and cardioprotective effects. It functions as a fluorochrome an antidepressant, a cardio protective agent, an(cholinesterase) inhibitor, an antioxidant, an antimicrobial, and a neuroprotective agent.
As an oxidation-reduction agent, methylene blue is used. The FDA has given the drug methylene blue approval to be administered intravenously to patients of all ages who have acquired methemoglobinemia.
When chloroquine (CQ) and other medications hit the market, it was no longer frequently used in Africa to treat malaria. Its potential as an antiseptic for the urinary tract has also been studied.
An investigational medicine being developed by the University of Aberdeen and TauRx Therapeutics that has been found to be an inhibitor of Tau protein aggregation in preliminary clinical studies is called methylthioninium chloride (INN, or methylene blue; suggested trade name ReMethylene Blueer).
The medication may be useful in the treatment of Alzheimer’s disease patients.
The amount of milliliters of a standard methylene blue solution that has been colored grey by 0.1 g of activated carbon is the methylene blue value.
Benefits of Methylene Blue IV Therapy
Methlylene Blue IV treats Malaria
Plasmodium falciparum is one malaria parasite that is increasingly resistant to standard antimalarial medications. Methylene blue has since been reviewed as a result. Methylene blue has been demonstrated to have exceptional antimalarial potency in cell culture tests (IC50 at only 4 nM). Animal investigations most critically demonstrate that methylene blue resistance is quite poor.
Methylene blue can cost as little as 5 cents US for 1 g.
Methlylene Blue IV acts as a neuroprotective agent
Methylene blue may protect against a nuMethylene Blueer of cytotoxicity-related disorders, including stroke and Parkinson’s disease, according to recent studies. Methylene blue has the ability to fight off malaria and methemoglobinemia because it is an electron carrier. It is also very helpful in cytotoxic conditions in the brain because it promotes cellular oxygen consumption and reduces anaerobic glycolysis.
Methylene blue has a nuMethylene Blueer of positive benefits, including a reduction in the formation of reactive oxygen species (ROS), protection against glutamate blockade, attenuation of the decline in mitochondrial meMethylene Bluerane potential, and defence against IAA neurotoxicity.
These advantages are especially important for diseases like Alzheimer’s, Parkinson’s, and stroke. Methylene blue has similar neuroprotective effects to antipsychotic medications like phenothiazine, but through a different mechanism, according to direct comparisons. Contrary to medications like phenothiazine, which act as free radical scavengers independently of the mitochondria, current research suggests that methylene blue functions as an antioxidant that is specific to the mitochondria.
Methylene blue can prevent and treat brain damage related to tumours in addition to illnesses like those mentioned above. Ifosfamide and other alkylating drugs are used to treat some forms of solid tumors, but they have the potential to damage the brain, which methylene blue may help to prevent. It is unclear exactly how methylene blue works to prevent brain damage in these circumstances, but it probably has something to do with how it oxidizes NADH and restores mitochondrial enzymes.
Methylene Blue IV acts as an anticancer drug
Because it has been demonstrated to be successful in causing the death of breast cancer cells, methylene blue is regarded as an anticancer medication.
It is a component of photodynamic therapy (PDT), a sort of treatment that uses visible light to obliterate tissue while also supplying oxygen and a photosensitizer. It was discovered that PDT employing METHYLENE BLUE causes breast cancer tumour cells to undergo significant cell death.
IV Methylene Blue enhances longevity
A potent antioxidant with anti-aging properties is methylene blue. When Methylene Blue was administered to the skin cells of middle-aged persons, researchers at the University of Maryland (UMD) discovered that the chemical accelerated cell division, decreased the amount of damaged molecules, and decreased the rate of cell death.
Methylene Blue continued to have positive effects when applied to skin cells from donors who were over the age of 80.
IV Methylene Blue enhances Memory Power
According to research, a single, tiny dose of Methylene Blue enhances brain activity in regions related to attention and short-term memory. In one study, methylene blue boosted performance on trials that gauged how quickly subjects could react to a visual stimuli. Short-term memory activities saw an increase in response, and memory retrieval tasks saw an increase in accurate answers of 7%. Methylene blue is a promising and secure treatment for memory enhancement as well as for the management of acute and long-term oxidative stress-related disorders, such as neurodegeneration and memory loss.
IV Methylene Blue prevents too low blood pressure or Hypotension
When a person is extremely ill, their blood pressure can occasionally fall to risky lows. This issue has the potential to be quite dangerous. Nitric oxide synthase and guanylate cyclase are both inhibited by Methylene Blue, which helps to alleviate the hypotension that is brought on by a number of conditions.
IV Methylene Blue provides treatment of rare genetic disorders
A uncommon progressive genetic illness called progeria, commonly known as Hutchinson-Gilford progeria syndrome, causes children to age quickly. The UMD research group demonstrated in 2015 that Methylene Blue could restore progeria-damaged skin cells. This indicates encouraging possibility for treating a condition that is now incurable.
IV Methylene Blue improves mitochondrial function
By acting as an antioxidant in the mitochondria at low concentrations, MB aids in the prevention of diseases brought on by abnormal mitochondria. Cellular Respiration production can rise when mitochondrial activity is enhanced. Most cellular processes use Cellular Respiration as their primary source of energy, thus when Cellular Respiration levels drop, so do physical and mental abilities.
History of Methylene Blue IV
Methylene Blue is blue in color. Since the late 19th century, it has been utilized as a textile dye. Additionally, it is utilized as a visual assistance during imaging or surgery to help clinicians distinguish between tissue, polyps, lesions, nerve fibers, and other structures. Escherichia coli and Staphylococcus aurous are just two of the germs Escherichia blue solution is effective against.
It turns out that methylene blue, which Heinrich Caro initially synthesized in 1876, has a number of health advantages. It is a medication that can be used to treat urinary tract infections when taken orally in tablet or capsule form. But it has also shown promise as a neuroprotectant, memory booster, antioxidant, and antidepressant.
In the lab, Ehrlich found that injecting Methylene Blue into animals caused it to concentrate swiftly in the brain. and have a remarkable capacity to target the body’s sick tissues with precision. Ehrlich gave this unusual activity that Methylene Blue demonstrated the nickname “Magic Bullet.” a word that is still in use today.
Since then, methylene blue has been used to treat dementia, chemotherapy for cancer, malaria, methemoglobinemia, urinary tract infections, cyanide and carbon monoxide poisoning, and dementia. German physician and Nobel Prize winner Paul Ehrlich made the first use of methylene blue to treat malaria in 1891.
The Mechanisms of Action for IV Methylene Blue
Methylene Blue functions as an alternative electron carrier in the electron transport chain in mitochondria. It accepts electrons from NADH and transfers them to cytochrome c. Cytochrome complex (cytochrome c) is a component of the electron transport chain in mitochondria.
Playing a role in apoptosis and as an antioxidant. Methylene Blue also stimulates glucose metabolism. Taken together, increases in CMRO2 and glucose uptake means that MB elevates oxygen consumption which helps glucose increase ATP production. Methylene Blue that differs significantly from conventional antioxidants. Superoxide is the first free radical to develop inside a cell during cellular respiration (O2).
Superoxide is reduced to water when methylene blue binds to it. It halts the oxidative cascade right when it starts. prior to it having a chance to cause harm.
So consider Methylene Blue to have a special dual quality. The synthesis of cellular energy is increased, which typically results in oxidative stress. Additionally, it reverses this oxidative damage. It’s an antioxidant and a metabolic booster.
Increases in ATP production provides more cellular energy for better overall brain function including cognition, mood and memory
When methemoglobinemia is present, methylene blue works primarily by converting the oxidised form of hemoglobin, Fe3+, to Fe2+.
As a result, the ability of hemoglobin to bind oxygen will be increased, increasing the amount of oxygen delivered to tissues. Vitamin C, an alternate therapy for methemoglobinemia, also possesses this ability.
The enzymes guanylate cyclase, endothelial nitric oxide synthase (eNOS), and inducible nitric oxide synthase (iNOS) are also inhibited by methylene blue.
This results in a reduction in the amount of cGMP required for the release of nitrous oxide, which causes blood vessels to constrict by inhibiting the relaxation of vascular smooth muscle.
How is Methylene Blue IV Therapy Used to Treat Medical Conditions
Methylene Blue might be helpful for enhancing some aspects of attention relating function and protecting dopaminergic cells. Methylene blue (MB), a synthetic small-molecule heterocyclic organic compound with strong antioxidant and cell energetic-enhancing properties, has recently been demonstrated to have significant positive effects in reducing nigrostriatal dopaminergic loss and motor impairment in acute toxin models of Parkinson’s disease.
Methylene Blue Treats Ringing Ears according to scientists of California Research Institution.
It seems like a sensible choice for prevention and therapeutic impact to use something like Methylene Blue, which increases energy at the cellular level and has undeniable neuroprotective advantages.
In summary, Methylene Blue boosts energy, strengthens cognitive functions, supports cure of depression, improves mental health, mood support & prevents low blood pressure.
IntravenousIV Methylene Blue Vs. Oral Supplementation
Methemoglobinemia is a condition that is treated with methylene blue injection. When the blood is unable to carry oxygen to the parts of the body that need it, this disease develops. Only a doctor or someone working closely with a doctor should administer this medication.
In a hospital, a nurse or other qualified healthcare provider will administer methylene blue. You receive methylene blue by having a needle inserted into a vein. Your IV tube must remain in place for five to thirty minutes in order to administer the medication slowly.
Through an IV, methylene blue is delivered into a vein. You will receive this injection from a healthcare professional. It may take up to 30 minutes to finish the IV infusion.
While you are receiving methylene blue, your respiration, blood pressure, oxygen levels, kidney function, and other vital signs will be constantly monitored. To confirm that the medication is functioning, your doctor will also need to test your blood. Methylene blue may only need to be administered once. If a second dose is required, it can be administered an hour after the first one.
Your urine or faeces will probably appear blue or green if you use methylene blue. This is a typical drug side effect that has no negative effects. With some urine tests, this impact, however, could produce unexpected findings.
Oral Methylene Blue Capsules are used 0.5 mg/kg of body weight is a safe starting dose, and lesser dosages are not harmful. The maximum dosage for rescue treatment, when the patient’s blood pressure is low, is 2 mg/kg.
Rescue dosages taken daily are not advised due to the danger of developing excessive blood pressure.
Oral source of Methylene Blue is pharmaceuticals, toxins or broad beans.
Molecular Structure of IV Methylene Blue
A salt of organic chloride with the chemical formula C16H18ClN3S is methylene blue. Methylthioninium chloride and Swiss Blue are other names for it.
IUPAC NAME: [7-(dimethylamino)phenothiazin-3-ylidene]-dimethylazanium;chloride.