This page covers Quercetin IV Therapy including its benefits. IV League provides mobile Quercetin IV Therapy.
Quercetin (flavonoid) is an antioxidant plant pigment found in numerous plants and foods including red wine, onions, green tea, apples, and berries.
The more general category of polyphenols includes quercetin. It is particularly prevalent among the flavonols, and unlike vitamins, when consumed, it is identified as a foreign chemical together with kaempferol, myricetin, and isorhamnetin.
The most prevalent forms of quercetin, especially in the population of plants, are quercetin-3-O-glucoside or as an aglycone.
The flavonoid in the diet that is most prevalent is quercetin. According to estimates, the average human takes in between 10 and 100 mg of it every day through a variety of food sources.
Onions, apples, grapes, berries, broccoli, citrus fruits, cherries, green tea, coffee, red wine, and capers are among the foods that frequently contain quercetin. It’s also offered as a powdered and capsule nutritional supplement.
People use this supplement for a variety of purposes, such as to increase resistance, reduce inflammation, reduce allergies, assist exercise performance, and preserve overall health.
It’s no secret that eating a diet full of vibrant fruits and veggies can help you prevent diseases like cancer, diabetes, and heart disease. But have you ever wondered how these plants manage to appear to have magical powers?
Bioflavonoids are one class of substance that plants have that is beneficial to health.
These are naturally present in many fruits and vegetables and support your body’s defense mechanisms against free radicals and other potentially harmful substances. A flavonoid known as quercetin is one of them that has been studied the most.
The plant pigment quercetin is a type of flavonoid which is a type of physiologically active molecule. Flavonoids are widely credited with many plants’ vibrant colors and healing properties.
Flavonols, a kind of flavonoid that contains quercetin, cannot be made by the human body. Many different plants, both edible and medicinal, contain this chemical. In addition, quercetin is available as a dietary supplement.
Quercetin strong antioxidant benefits have been proven in clinical investigations. Antioxidants are substances that protect your cells from the unstable and disease-causing free radicals that speed up the aging process.
The Benefits of Quercitin IV Therapy
Quercetin has a potent potential to inhibit the growth of both bacteria and fungi, according to antimicrobial studies. According to Yang (2020), the flavonoid quercetin inhibits the growth of specific bacteria by altering or breaking the bacterial cell wall; interfering with how bacteria generate and express proteins and enzymes; preventing bacteria from adhering to other cells; preventing bacteria from producing DNA and RNA.
While Quercetin’s efficacy is significantly increased when paired with the antifungal drug amphotericin B, its effect on fungi is not as strong as it is on bacteria.
According to reports, quercetin possesses long-lasting anti-inflammatory properties. Numerous different cell types in both animals and people have been proven to be impacted by these potent anti-inflammatory properties.
Quercetin contains antioxidant and inflammatory attributes which can be used in dealing with widespread disorders of allergy. It has been demonstrated that quercetin may strengthen the immune system. It can stop the body from releasing histamine and other compounds that cause allergies.
Additionally, it has been demonstrated to stabilize the mast cell membrane, suggesting that it can assist in the treatment of diseases linked to mast cells, such as rheumatoid arthritis, sinusitis, and asthma.
Some data suggests quercetin may be able to reduce blood pressure. In comparison to a placebo, one study found quercetin to significantly lower blood pressure; however, additional research is required to determine the effects and the most effective dosage. Quercetin may one day be used in addition to conventional antihypertensive drugs to provide additional benefits.
Animal studies have demonstrated that quercetin can help cure and stop the spread of cancer cells. Cancers of the lungs, prostate, liver, breast, colon, skin, ovary, and cervical follicles are among them. Its capacity to assist in regulating the routes that cancer uses to spread gives it anti-cancer effects. Additionally, it aids in promoting cancer cells’ apoptosis (self-destruction).
Quercetin being an antioxidant assists in reducing oxidative stress, which can harm your body’s DNA, it helps to halt a process that might otherwise result in the growth of cancer cells.
According to research, the antioxidant properties of quercetin may help prevent degenerative brain diseases including Alzheimer’s and dementia. In one experiment, mice with Alzheimer’s disease were injected with quercetin every two days for three months. At the conclusion of the trial, the injections had reversed multiple Alzheimer’s disease signs, and the mice had significantly improved on learning tests. In a different study, mice with early-stage middle-stage Alzheimer’s disease showed enhanced brain function after eating a diet high in quercetin. On the other hand, animals with middle-late stage Alzheimer’s showed little to no response to the diet.
Coffee is a well-liked beverage that may reduce your risk of developing Alzheimer’s. In fact, research indicates that the main component in coffee that is responsible for its possible anti-inflammatory properties is quercetin, not caffeine.
Even though these results are encouraging, further human study is still required.
Three essential characteristics of quercetin flavonol distinguish it: immunomodulatory, anti-inflammatory, and antioxidant. Quercetin is a fantastic choice for treating conditions in which oxidative stress, inflammation, and the immune system are involved. This combination of these three qualities provides a source which reflects the efficacy of a quercetin-based dietary supplement taken orally in preventing Covid-19 infection.
History of Quercitin IV
Albert Szent-Györgyi discovered flavonoids in 1936 while researching ways to treat scurvy. He won the Nobel Prize in 1937 for his “discoveries in connection with the biological combustion processes with special reference to vitamin C and the catalysis of fumaric acid.
Named after the oak genus Quercus, quercitin has been in use since 1857 and comes from the Latin word quercetum, which means “oak woodland.” It is a polar auxin transport inhibitor that is found naturally. One of the most prevalent dietary flavonoids, quercetin is consumed on average 25 to 50 mg per day.
Highest intake of querticin was discovered in raw and canned capers, raw lovage leaves, dock like sorrels, radish leaves, carob fiber, fresh dill weed, cilantro, raw yellow wax pepper, fennel leaves. The outermost rings and the area nearest to the root of red onions have higher levels of quercetin, with the latter region having the highest concentration. According to one study, tomatoes produced organically have 79% more quercetin than non-organically farmed fruit. Different types of honey from various plant sources contain quercetin.
The primary class D Beta-lactamase, OXA-48, was discovered in Turkey in 2001 and has subsequently spread widely throughout the world.OXA-48 Beta-lactamase-mediated carbapenem resistance in Enterobacteriaceae is a significant danger to global health and has expanded quickly in many parts of the world.
Antibiotic resistance can potentially be overcome by creating inhibitors. Additionally, in a mouse infection model, quercetin and piperacillin demonstrated antibacterial effectiveness.
These research offer prospective lead compounds for the creation of Beta-lactamase inhibitors as well as for use in conjunction with Beta-lactams to treat pathogens that produce OXA-48.The alternatives for troublesome OXA-48 are, however, limited. Quercetin was located here.
The Mechanisms of Action for Quercitin IV
Mechanisms of action of the pleiotropic effects of quercetin include enhanced glucose uptake by peripheral tissues, reduction of intestinal glucose absorption, and stimulation of insulin secretory and sensitising actions. Early research revealed quercetin has a low bioavailability.
Quercetin, however, has a lengthy half-life in the human body and has been found in plasma following food or supplement consumption, according to recent findings.
Despite the abundance of in vitro and in vivo data demonstrating quercetin’s antidiabetic potential, its effectiveness in diabetic human beings has not yet been investigated.
The flavonol quercetin is one of the most often found and thoroughly researched flavonoids. Its potent anti-inflammatory and antioxidant properties are well known and are believed to help treat and prevent diseases like diabetes, cancer, neurodegenerative diseases, and cardiovascular diseases.
According to research, quercetin regulates whole-body glucose homeostasis through interacting with a variety of molecular targets in the liver, pancreas, skeletal muscle, adipose tissue, and small intestine.
How is Quercitin IV Used to Treat Medical Conditions?
Treatment of Metabolic Syndrome’s abnormalities
A flavonoid called quercetin, which is found in many fruits and vegetables, has positive effects on metabolic syndrome-related disorders. We employed a genetic model of metabolic syndrome in this study to examine the metabolic and transcriptome responses to quercetin supplementation. Male adult rats of the PD/Cub strain were fed either a high-sucrose diet (10 g quercetin/kg diet; PD-Q rats) or an HSD without quercetin (10 g HSD; control PD rats). The transcriptome profiles of the liver and retroperitoneal fat, as well as morphometric and metabolic characteristics, were evaluated.
In rats treated with quercetin, the relative weights of epididymal and retroperitoneal fat were dramatically reduced. Additionally, PD-Q rats had a lower level of fasting insulin and a smaller area under the glycemic curve. Although there were no changes in total cholesterol levels, the PD-Q rats’ liver and serum both had lower levels of triglycerides overall. The liver’s and the adipose tissue’s transcriptome profiles supported the metabolic and morphometric results, showing a pattern compatible with modifications that make insulin more sensitive. The main regulator nodes were Pparg, Adipoq, Nos2, and Mir378. In summary, quercetin supplementation reduces metabolic syndrome-related disorders such obesity, dyslipidemia, and glucose intolerance.
Treatment of Type 2 Diabetes
The bioflavonoid quercetin, which is prevalent in foods like grapefruit, onions, and berries, has a wide range of therapeutic applications, primarily for the treatment of Type 2 diabetes and associated consequences. In cell line models, quercetin demonstrated effects that were comparable to those of metformin, a commonly prescribed antidiabetic medication. It also shows promise as a treatment for diabetes and associated pathophysiological consequences in in vivo studies.
The bioflavonoid quercetin, which is prevalent in foods like grapefruit, onions, and berries, has a wide range of therapeutic applications, primarily for the treatment of Type 2 diabetes and associated consequences. In cell line models, quercetin demonstrated effects that were comparable to those of metformin, a commonly prescribed antidiabetic medication. It also shows promise as a treatment for diabetes and associated pathophysiological consequences in in vivo studies.
Through an unique fermentation-based glycosylation technique using inexpensive substrates, quercetin can be synthesised on a large scale and used as a dietary supplement. The review focuses on the growing body of evidence supporting quercetin as a promising treatment option for type 2 diabetes and its pathophysiological consequences caused by oxidative stress.
The various targets of diabetes that quercetin affects as well as the main signalling pathways it regulates help to reduce Type 2 diabetes complications as well as its symptoms. However, more research is required to increase quercetin’s bioavailability and create a dose schedule.
Treatment of Chronic diseases like hypertension & Neurodegenerative diseases
According to mounting evidence, the majority of neurodegenerative disorders are caused by oxidative stress, which is linked to ageing. Polyphenols serve as antioxidants to lower the risk of neurodegenerative diseases. A flavonoid called quercetin can be found in a variety of plant foods that are frequently eaten as part of a normal diet.
It demonstrates several biological traits linked to its antioxidant activity. This review evaluates quercetin’s molecular make-up, dietary sources, and bioavailability.
Additionally, the key findings from in vitro research looking at the processes by which quercetin exerts its antioxidant activity are reported. The majority of these effects, meanwhile, have only been seen in vitro, and there aren’t many clinical studies available.
Intravenous Vs. Oral Supplementation
In 1975, six healthy human volunteers received a fixed dose of 100 mg of quercetin intravenously in an ethanol carrier without experiencing any negative side effects. This investigation also showed that oral administration of the drug has very low oral bioavailability.
Another clinical experiment was conducted in 1996, around 20 years later. This trial was an escalation Phase I trial with an intravenous beginning dose of 60 mg/m2.
This starting dose was determined based on the earlier volunteer study from 1975. Then, doses were raised until the maximum safe dose, 1400 mg/m2, was discovered and recommended for Phase II trials, administered either at 3-week or weekly intervals.
According to tradition, Phase I studies should result in a recommendation of the dose to be investigated in Phase II studies. But in addition to establishing the suggested dosage, this study also showed that quercetin has anticancer properties.
One patient with cisplatin-resistant ovarian cancer in particular experienced a significant and long-lasting decline in serum CA 125 levels. Another hepatocellular cancer patient saw a decrease in a-fetoprotein from 460 to 40.
Although the results of this research clearly showed quercetin’s safety against cancer, the scientists came to the following conclusion: “In conclusion, quercetin can be safely delivered by injection of a bolus-sized dosage. Evidence of anticancer efficacy was observed, and the plasma levels attained suppressed lymphocyte tyrosine kinase activity. However, no further testing was done following this study.
As Oral Supplementation, Hospitals administer quercetin as a medication in form of capsules of 500mg for conditions other than cancer. Depending on the source, a vial of active bioflavonoid preparation comprises 500 mg (450 mg of polyvinylpyrrolidone and 50 mg of quercetin in 500 mg of powder form). The dosage is to be administered for reasonable times likewise 500mg being used for twice a day on monthly basis. The price ranges from 10 to 20 euros.
There is a lot of quercetin in food and nature. Between 5 and 40 milligrams are normally obtained through food each day. However, you can consume up to 500 milligrams every day if you consume a lot of fruits and vegetables.
Molecular Structure of Quercetin IV
The molecular formula of IV Quercetin is C15H10O7 and its molecular weight is 338.27. The IUPAC name of IV Quercetin is 2-(3,4-dihydroxyphenyl)-3,5,7-trihydroxychromen-4-one;dihydrate.
