This page covers Vitamin D IV Therapy including its many benefits. IV League provides mobile Vitamin D IV Therapy.
Vitamin D is a necessary vitamin that aids in controlling the body’s levels of calcium and phosphorus. It also contributes to preserving healthy bone structure.
There are several types of vitamin D, including cholecalciferol and ergocalciferol (vitamin D2) (Vitamin D3). Eggs, milk with added vitamin D, and fish all contain vitamin D. When the skin is exposed to sunshine, it also produces it. When there is sunlight, vitamin D is stored in fat and released when there isn’t any sunlight.
To treat and prevent vitamin D insufficiency, supplements with vitamin D are frequently utilized. People at risk for deficiency include those who don’t get enough sun and those who are 65 or older. People also utilise vitamin D for heart disease, asthma, hay fever, weak and brittle bones, and many other ailments, although many of these claims are not well-supported by science.
Additionally, there is little solid data to back up the use of vitamin D supplementation for COVID-19. But it’s crucial to keep your vitamin D levels in check. This can be accomplished by taking 400–1000 IU of vitamin D daily or by basking in the sun for 15–30 minutes each day.
Technically, vitamin D isn’t even a vitamin. It is a specific class of fat-soluble hormone that the body produces.
This is accomplished by the sun’s radiation turning into vitamin D when it enters the skin. You might not, however, acquire enough vitamin D from sunshine due to a number of causes.
These include using sunscreen with UV protection, spending too much time indoors, and being exposed to pollution and cloud cover, which prevent UV rays from reaching the earth’s atmosphere in full.
You might try changing your diet if you don’t receive enough sunlight to create vitamin D. Some foods, like liver, cheese, and fatty fish like salmon and tuna, naturally contain vitamin D.
Foods like various dairy products, juices, and cereals that have been fortified with vitamin D commonly include it as well. People who do not consume enough vitamin D to meet the recommended daily intake for adults—600 to 800 international units (IU)—can try taking supplements.
- Two forms of Vitamin supplements have been introduced:
- Vitamin D2 (ergocalciferol)
- Vitamin D3 (cholecalciferol)
Because it often does a better job of increasing the blood levels of vitamin D, vitamin D3 is frequently favored as a supplement.
Benefits of Vitamin D IV Therapy
Because vitamin D is so vital to the body, these injections can improve your health. It is one of the potential advantages:
Because it aids the body in absorbing calcium, which strengthens bones, vitamin D helps prevent brittle, weak bones and lessens the risk of osteoporosis, which can arise from them. Osteomalacia, a disorder caused by inadequate vitamin D intake, can result in both bone pain and muscular weakness.
A healthy heart
Vitamin D may offer essential assistance in decreasing cholesterol and keeping healthy blood vessels, which may lower high blood pressure (to cut the risk of atherosclerosis, plaque buildup on blood vessel walls).
A responsive immune system
Immune support from vitamin D may help the body fight off pathogens that cause colds, the flu, and other ailments. It might also be successful at reducing inflammation signs brought on by autoimmune illnesses.
Vitamin D may be helpful if you suffer from mood disorders like depression; some evidence suggests a connection between depressive symptoms and low blood levels of vitamin D.
Numerous vitamin D receptors have been discovered in the brain, and they are essential for maintaining cognitive function throughout life as well as for brain development in fetuses.
Diabetes and weight loss support
Obesity and diabetes have been associated with low vitamin D levels. Eliminating a vitamin D deficiency may improve weight loss attempts and help control the symptoms of diabetes.
History of Vitamin D IV Therapy
Prior to the 20th century, the components of a diet that could support the survival, development, and reproduction of higher animals could not be identified. When McCollum and Davis discovered vitamin A in 1913, a new era of food additives began, leading to the accomplishment of that objective. It also covered the discovery of vitamin D and how ultraviolet light causes skin to produce it.
The physiological processes it underwent to produce a healthy skeleton and more were then described. Vitamin D is changed into a hormone that works by way of a nuclear receptor to perform these actions. The research that supported this idea is given, along with its relevance to biology and medicine.
The extraordinarily high incidence of rickets in the UK, especially in Scotland, had Sir Edward Mellanby in Great Britain exceedingly worried. In fact, the illness was dubbed “the English Disease.”
After reading McCollum’s findings, Sir Mellanby came to the conclusion that rickets might be a condition caused by nutritional deficiencies. He very cunningly gave oats, a staple of the Scottish diet, to dogs that he unwittingly kept indoors and out of the sun.
The Scottish had the highest incidence of rickets. They acquired rickets, which is the same illness as in humans. Sir Mellanby believed that vitamin A might be to blame for preventing rickets because he could treat the condition by giving cod liver oil.
Following this discovery, McCollum, who had since relocated from Wisconsin to Johns Hopkins University, sought to investigate the possibility that vitamin A was responsible for curing rickets.
He showed that while the vitamin A in cod liver oil was destroyed when oxygen was bubbled through it, rickets could still be treated even though the preparation lost its capacity to prevent xerophthalmia and vitamin A deficiency.
McCollum et al. accurately deduced that a new vitamin, which they labeled Vitamin D, is the component that cures rickets.
The Mechanisms of Action for Vitamin D IV Therapy
The majority of people naturally produce enough vitamin D through regular dietary consumption (found in select foods like eggs, salmon, and cheese) and photochemical conversion of the vitamin D3 precursor 7-dehydrocholesterol in the skin as a result of sunshine exposure.
On the other hand, vitamin D deficiency can frequently result from a combination of limited sun exposure, inadequate vitamin D intake, genetic abnormalities with endogenous vitamin D receptor, or even serious liver or kidney disease.
It is recognized that such a shortage can cause diseases like rickets or osteomalacia, which all exhibit deficient bone mineralization, increased compensatory skeletal demineralization, lower blood calcium ion concentrations, and increased synthesis and release of parathyroid hormone.
The mobilization of skeletal calcium and the renal excretion of phosphorus are stimulated by increases in parathyroid hormone. This increased skeletal calcium mobilization causes porotic bone diseases.
Vitamin D3 and vitamin D2 are typically available as dietary supplements in a variety of foods and pharmaceuticals, despite the fact that vitamin D3 is produced naturally in the skin through photochemical reactions.
By improving the efficiency of the small intestine to absorb these minerals from the meal, vitamin D helps to maintain appropriate levels of serum calcium and phosphorus in the bloodstream. Vitamin D3 or D2 is hydroxylated in the liver to 25-hydroxyvitamin D, which is then further hydroxylated in the kidney to become the major active metabolite 1,25-dihydroxyvitamin D.
This final metabolite binds to endogenous vitamin d receptors, causing a variety of regulatory effects, such as maintaining calcium balance, controlling parathyroid hormone, encouraging renal calcium absorption, increasing intestinal calcium and phosphorus absorption, and mobilizing calcium and phosphorus from bone to plasma to keep levels of each mineral balanced in bone and plasma.
The hormonally active form of vitamin D is 1,25(OH)2D3, or 1,25-dihydroxvitamin D3. The 1,25(OH)2D3 activated vitamin D receptor/retinoic X receptor (VDR/RXR) heterodimeric complex directly binds to certain DNA sequences as part of the genomic mechanism of 1,25(OH)2D3 activity.
Genome-wide investigations have revealed that 1,25(OH)2D3 regulates gene activity at a variety of sites many kilobases away from the transcription start site. Numerous VDR co-regulatory proteins have been found, and these studies have led to the identification of numerous VDR proteins.
Cryoelectronic microscopy, X-ray scattering, and hydrogen deuterium exchange were recently used to study the structure of the liganded VDR/RXR complex. These latest technical developments will lead to a more thorough understanding of VDR coactivator interactions, making it easier to develop clinical applications that are unique to particular cells and genes.
Other fundamentally important subjects in the field include the identification and functional significance of proteins involved in the metabolism of vitamin D. Although the identification of mechanisms mediating VDR-regulated transcription has been one focus of recent study in the field.
The most significant 25-hydroxylase has been identified as CYP2R1, and research demonstrating that inactivating mutations in CYP24A1 are likely to be the cause of idiopathic infantile hypercalcemia point to CYP24A1 playing a crucial role in humans.
Additionally, studies using knockout and transgenic mice have shed new light on the physiological function of vitamin D in traditional target tissues and shown evidence of 1,25(OH)2D3’s extra skeletal effects, such as the prevention of cancer progression, effects on the cardiovascular system, and immunomodulatory effects in some autoimmune diseases. Humans have also seen some of the mechanistic discoveries that were seen in animal models.
The discovery of comparable pathways in humans may result in the creation of fresh treatments for illness prevention and treatment.
The effectiveness of intestinal calcium and phosphorous absorption is raised by calcitriol’s interaction with vitamin D receptors in the small intestine from around 10-15% to 30-40% and 60% rose to 80%, respectively.
Additionally, calcitriol interacts with vitamin D receptors in osteoblasts to induce a receptor activator of nuclear factor kB ligand (or RANKL), which then stimulates immature preosteoclasts to mature into bone-resorbing osteoclasts by interacting with NFkB.
Such mature osteoclasts ultimately serve to maintain blood calcium and phosphorus levels by removing calcium and phosphorus from bone. Additionally, calcitriol promotes calcium reabsorption from the kidneys’ glomerular filtrate.
Furthermore, it is thought that when calcitriol connects with nuclear vitamin D receptors, the resulting complex then attaches to retinoic acid X receptor (RXR) to form a heterodimeric complex, which then binds to particular DNA nucleotide sequences known as vitamin D response elements.
Different transcription factors bind to this complex when bound, up- or down-regulating the activity of the linked gene. It is estimated that between 200 and 2000 genes have vitamin D response elements or are indirectly impacted to regulate a large number of genes throughout the genome.
Cholecalciferol is thought to control gene transcription in this way, reducing the risk of cancer, autoimmune diseases, and cardiovascular disease connected to vitamin D insufficiency. In fact, some studies have suggested that calcitriol may be able to inhibit angiogenesis, promote apoptosis, and induce cellular maturation in order to prevent the development of malignancies.
It may also have anti-inflammatory effects by preventing foam cell formation and promoting angiogenesis in endothelial colony-forming cells in vitro. It may also be able to inhibit immune responses by enhancing the transcription of endogenous antibiotics like cathelicidin.
How is Vitamin D IV Therapy Used to Treat Medical Conditions
- Common viral skin infections called warts are typically treated with invasive procedures like electrocautery, cryotherapy, or laser ablation. To assess the effectiveness of intralesional vitamin D3 injection in the treatment of common warts, topical vitamin D has been utilized with varying degrees of success.
- Treatment for rickets can be given either as a daily dose of 15,000 mcg (600,000 U) of vitamin D or gradually over a period of many months. If the progressive approach is chosen, until healing is well-established and the alkaline phosphatase concentration is nearing the reference range, 125-250 mcg (5000–10,000 U) is given every day for 2–3 months.
- An uncommon, genetic bone condition characterized by low blood phosphate levels (familial hypophosphatemia). People with low blood phosphate levels can cure bone diseases by taking phosphate supplements and certain forms of vitamin D, termed calcitriol or dihydrotachysterol, orally.
- Parathyroid gland is inactive (hypoparathyroidism). In persons with low parathyroid hormone levels, oral administration of particular forms of vitamin D, such as dihydrotachysterol, calcitriol, or ergocalciferol, is beneficial in raising calcium levels in the blood.
- Deterioration of the bones (osteomalacia). This illness can be effectively treated by ingesting vitamin D3.
- A bone condition that affects individuals with kidney dysfunction (renal osteodystrophy). People with renal failure who take a special type of vitamin D by mouth, termed calcitriol, are able to control low calcium levels and stop bone loss.
Intravenous Vitamin D IV Therapy vs Oral Supplementation
The bloodstream receives a direct dosage of vitamin D3 by injection. For anyone who wants to concentrate on raising their vitamin D levels, this makes these shots extremely beneficial. Additionally, IVs provide vitamin D to the bloodstream for quick, effective absorption. A sterile saline solution and a variety of nutrients are typically included in an IV bag along with vitamin D.
These two alternatives are both better than the majority of oral supplements. It takes time to digest pills, tablets, or liquids, which reduces the quantity that is absorbed into the bloodstream.
According to studies, blood 25-hydroxyvitamin D (25OHD) concentrations of roughly 30 ng/mL are ideal for maintaining bone health and having additional skeletal effects. Vitamin D insufficiency has been treated with both cholecalciferol (Vitamin D3) and ergocalciferol (Vitamin D2).
All adults who are vitamin D deficient should be treated with 50,000 IU of vitamin D2 or vitamin d3 once a week for eight weeks, or its equivalent of 6,000 IU of vitamin d2 or vitamin d3 daily, according to the Endocrine Society.
This treatment should be followed by maintenance therapy at 1500–2000 IU/d. The severity of the deficiency or the person’s body weight are not factors considered in this advice.
Molecular Structure of Vitamin D IV
The molecular formula of Vitamin D IM Injection is C29H50O2 and its molecular weight is 430.7. The IUPAC name of Vitamin D IM Injection is (2R)-2,5,7,8-tetramethyl-2-[(4R,8R)-4,8,12-trimethyltridecyl]-3,4-dihydrochromen-6-ol.